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DATURA BLOCKS ACETYLCHOLINE IN THE BODY AND BRAIN
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OKAY BACK FROM THE POISON CENTER ☎️
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A 32 YEAR OLD MAN IN A QATAR EMERGENCY ROOM 🫀
A 2021 Case Report Describes A 32 Year Old Man In Qatar
He Was Brought To The Emergency Department
Doctors Found Him Confused And Delirious
Agitation And Aggressive Behavior Were Also Noted
His Family Said He Had Eaten Jimsonweed Seeds Boiled In Milk
That Was Three To Four Hours Before He Arrived
They Brought The Plant With Them
The Plant Does Not Grow Naturally In Qatar
He Told Doctors He Had Grown It Himself For Its Seeds
An ECG Showed A Fast Heart Rhythm Of 118 Beats Per Minute
Otherwise His Vital Signs Were Stable
His Skin Was Dry And Flushed
The Exam Also Found Dilated Pupils
He Scored 10 Out Of 15 On The Glasgow Coma Scale
A Toxicology Team Suspected Anticholinergic Activity From The Plant
The Team Recommended Supportive Measures Only
Benzodiazepines Were Given For His Agitation
He Spent Two Days In Intensive Care
After That He Returned To His Usual State And Went Home
The Paper Reports No Complications Afterward
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WHAT THE DATURA PLANT CONTAINS ⚗️
Datura Stramonium Is Also Called Thorn Apple Or Jimsonweed
It Contains Atropine Scopolamine And Hyoscyamine
Those Chemicals Give It Anticholinergic Effects When Eaten
A CDC Report Calls It A Plant In The Nightshade Family
The Report Links It To Anticholinergic Type Poisoning
Doctors In Winnipeg Reviewed Four Datura Poisonings From 2006
Their Paper Calls The Same Three Chemicals Belladonna Alkaloids
They Are Found In The Seeds Roots Flowers And Stems
Their Primary Actions Are Anticholinergic
The Qatar Authors Say The Seeds Have The Highest Toxin Concentration
Datura Is Sometimes Used Recreationally They Write
People Take It For Its Hallucinogenic And Euphoric Effects
The Seeds Have Been Used This Way For Centuries They Note
That CDC Report Also Says Poisoning Can Occur Among Many Age Groups
Younger People Typically Eat It For Recreational Purposes
People Of Any Age Might Also Eat It Without Knowing
Winnipeg Doctors Say Teens Not Uncommonly Eat Anticholinergic Plants
Datura Is Toxic Because It Blocks A Body Chemical Called Acetylcholine
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WHAT BLOCKING ACETYLCHOLINE DOES 🧠
Winnipeg Doctors Explain How The Poisoning Works
The Alkaloids Block Acetylcholine At Its Muscarinic Receptors
That Blockade Is Called Competitive
It Happens In The Brain And Spinal Cord And Outside Them
End Organs Of The Parasympathetic Nervous System Are Affected Too
Qatar Doctors List The Known Signs Of Datura Poisoning
Dry Skin And Flushing Were Both Evident In Their Patient
So Were Dilated Pupils And A Fast Heart Rhythm
Other Signs Include Slower Bowel Activity And Urinary Retention
High Body Temperature Can Also Occur
Muscle Breakdown And Multiorgan Failure Are Possible
Neurological Signs Include Disorientation And Confusion
Short Term Memory Can Be Impaired
Hallucinations Can Be Visual Or Auditory
Psychosis And Agitated Delirium Can Also Occur
The List Ends With Seizures And Coma
Winnipeg Doctors Trace The Delirium To The Poison In The Seed
Their Paper Calls That Poison An Anticholinergic Substance
Qatar Doctors Say These Effects May Last 24 To 48 Hours
Mild Cases Can Resolve Within Six Hours
Moderate To Severe Cases Take Longer
The Man In Qatar Needed 48 Hours In Intensive Care To Fully Recover
