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WHY THE WEAKEST OPIOID STILL KILLS
Most people think all opioids are the same beast
Codeine Is The One Sitting In Your Medicine Cabinet
It Sounds Gentle Next To The Names On The News
Reality Is Stranger Than That
The Same Pill Can Be Harmless For You And Deadly For The Person Next To You
Your Own Liver Decides Which One It Is
This Is Where Codeine Stops Being Simple
THIS NEWSLETTER IS FOR INFORMATIONAL PURPOSES ONLY. NOTHING IN THIS CONTENT CONSTITUTES MEDICAL, PSYCHOLOGICAL, OR PROFESSIONAL ADVICE. ALWAYS CONSULT A QUALIFIED HEALTHCARE PROFESSIONAL BEFORE MAKING ANY HEALTH RELATED DECISIONS
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HOW IT DIFFERS FROM THE REST 🪜
Codeine Sits At The Bottom Of The Opioid Ladder
On Its Own It Barely Works
It Is A Prodrug Which Means Your Liver Has To Turn It Into Morphine First
Only About Ten Percent Ever Makes That Jump
That Is Why It Feels Mild Next To The Heavy Names
Here Is Where It Lands On The Scale
CODEINE ★ Roughly One Tenth As Strong As Morphine
MORPHINE ★ The Baseline Every Opioid Gets Measured Against
OXYCODONE ★ About One And A Half Times Stronger Than Morphine
HEROIN ★ Stronger Than Morphine And Reaches The Brain Far Faster
FENTANYL ★ Roughly Fifty To One Hundred Times Stronger Than Morphine
Codeine Is Not Just A Weaker Version Of Every Drug We Have Covered
Benzos Calm You By Acting On Gaba Receptors In The Brain
Codeine Works On The Mu Opioid Receptors Instead
Two Different Systems And Two Different Doors Into The Body
Caffeine Pushes The Opposite Way As A Stimulant That Speeds You Up
Codeine Is A Depressant That Slows Everything Down Including Your Breathing
Mixing It With Benzos Or Alcohol Stacks Two Depressants And That Is When People Stop Breathing
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WHEN IT IS GIVEN AND WHY 🩺
Doctors Reach For Codeine When The Pain Is Mild To Moderate
It Also Quiets A Stubborn Cough Which Is Why It Shows Up In Some Syrups
The Most Common Form Pairs It With Acetaminophen
You May Know It As Tylenol With Codeine Number Three
On Paper It Is One Of The Gentler Options A Doctor Can Write
Here Is The Catch Nobody Mentions At The Counter
The Same Dose Does Not Hit Two People The Same Way
A Liver Enzyme Called CYP2D6 Decides How Much Becomes Morphine
Some People Barely Convert Any And Feel Almost Nothing
Others Convert It Fast And Get A Much Bigger Hit Than Intended
Your Genes Wrote That Rule Long Before You Swallowed The Pill
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The People Who Convert Fastest Are Called Ultra Rapid Metabolizers
Their Bodies Flood With Morphine From A Normal Codeine Dose
For A Small Child That Flood Can Be Fatal
Children Died After Routine Tonsil And Adenoid Surgery While Taking Codeine For Pain
Many Of Them Carried The Ultra Rapid Genetics Without Anyone Knowing
In 2017 The FDA Contraindicated Codeine For Children Under Twelve
Strong Warnings Went Up Against Use In Teens After Those Surgeries
Regulators Also Warned Breastfeeding Mothers After An Infant Death
Linked To An Ultra Rapid Mother
Her Milk Carried The Morphine Straight To The Baby
The Mechanism Behind Every One Of These Deaths Is The Same
Too Much Morphine Slows Breathing Until It Stops
That Risk Climbs Sharply When Codeine Meets Alcohol Or Benzos Or Other Depressants
Weak On The Ladder Does Not Mean Safe In The Body
